Marine ω-3 polyunsaturated fatty acids and risk of colorectal cancer according to microsatellite instability.

ABSTRACT:

Background

Chronic inflammation is involved in the development of colorectal cancer (CRC) and microsatellite instability (MSI), a distinct phenotype of CRC. Experimental evidence indicates an anti-inflammatory and antineoplastic effect of marine ω-3 polyunsaturated fatty acids (PUFAs). However, epidemiologic data remain inconclusive.

Methods

We investigated whether the association between marine ω-3 PUFAs and CRC varies by MSI-defined subtypes of tumors in the Nurses' Health Study and Health Professionals Follow-up Study. We documented and classified 1125 CRC cases into either MSI-high tumors, in which 30% or more of the 10 microsatellite markers demonstrated instability, or microsatellite-stable (MSS) tumors. Cox proportional hazards model was used to estimate the hazard ra

SUBMITTER: Song M 

PROVIDER: S-EPMC4402363 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature