Urinary biomarkers and renal near-infrared spectroscopy predict intensive care unit outcomes after cardiac surgery in infants younger than 6 months of age.

ABSTRACT:

Objective

To assess the ability of urinary acute kidney injury biomarkers and renal near-infrared spectroscopy (NIRS) to predict outcomes in infants after surgery for congenital heart disease.

Methods

Urinary levels of neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), and cystatin C were measured preoperatively and postoperatively in 49 infants younger than 6 months of age. Renal NIRS was monitored for the first 24 hours after surgery. A composite poor outcome was defined as death, the need for renal replacement therapy, prolonged time to first extubation, or prolonged intensive care unit length of stay.

Results

Forty-two (86%) patients had acute kidney injury as indicated by at least Acute Kidney Injury Netwo

SUBMITTER: Hazle MA 

PROVIDER: S-EPMC3653979 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature