Treatment effects on measures of body composition in the TODAY clinical trial.

ABSTRACT:

Objective

The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial showed superiority of metformin plus rosiglitazone (M+R) over metformin alone (M), with metformin plus lifestyle (M+L) intermediate in maintaining glycemic control. We report here treatment effects on measures of body composition and their relationships to demographic and metabolic variables including glycemia.

Research design and methods

Measures of adiposity (BMI, waist circumference, abdominal height, percent and absolute fat, and bone mineral content [BMC] and density [BMD]) were analyzed as change from baseline at 6 and 24 months.

Results

Measures of fat accumulation were greatest in subjects treated with M+R and least in M+L. Although fat measures in M+L were less than tho

SUBMITTER: TODAY Study Group 

PROVIDER: S-EPMC3661839 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature