Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population.

ABSTRACT:

Introduction

Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined.

Objective

To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer.

Material and methods

FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay.

Results

Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04

SUBMITTER: Mohapatra S 

PROVIDER: S-EPMC3668239 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature