Cluster analysis reveals differential transcript profiles associated with resistance training-induced human skeletal muscle hypertrophy.

ABSTRACT: Using genomic microarray analysis, we sought to identify and annotate differences in the pretraining skeletal muscle transcriptomes among human subjects clustered as nonresponders (Non), modest responders (Mod), and extreme responders (Xtr) based on differential magnitudes of myofiber hypertrophy in response to progressive resistance training (RT) (Non-6 μm², Mod 1,111 μm², or Xtr 2,475 μm²). In prior work, we noted differences among clusters in the prevalence of myogenic stem cells prior to and during RT (35), and in the translational signaling responses to the first bout of resistance exercise (30). Here we identified remarkable differences in the pretraining transcript profiles among clusters (8,026 gene transcripts differentially expressed between Xtr and Non, 2,463 between Xtr and Mod

SUBMITTER: Thalacker-Mercer A 

PROVIDER: S-EPMC3680779 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature