Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis.

ABSTRACT:

Introduction

Severe sepsis is characterised by intravascular or extravascular infection with microbial agents, systemic inflammation and microcirculatory dysfunction, leading to tissue damage, organ failure and death. The growth factor angiopoietin (Ang-1) has therapeutic potential but recombinant Ang-1 tends to aggregate and has a short half-life in vivo. This study aimed to investigate the acute effects of the more stable Ang-1 variant matrilin-1-angiopoietin-1 (MAT.Ang-1) on the function of the microcirculation in an experimental model of sepsis, and whether any protection by MAT-Ang-1 was associated with modulation of inflammatory cytokines, angiogenic factors or the endothelial nitric oxide synthase (eNOS)-Akt and vascular endothelial (VE)-cadherin pathways.

Methods

Alu

SUBMITTER: Alfieri A 

PROVIDER: S-EPMC3682284 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature