Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye.

ABSTRACT:

Purpose

To evaluate the efficacy and safety of two ophthalmic solutions in patients with mild to moderate dry eye.

Methods

We performed a prospective, 2-month-long, randomized, double-blind, single-center, parallel clinical trial to compare the efficacy and safety of two ophthalmic solutions for dry eye treatment. Patients were randomly assigned to one of the two treatment groups, study group or active-control group, and received one drop four times a day. The primary efficacy endpoint was to extend the tear film break-up time (TBUT) after 2 months of treatment. The Ocular Surface Disease Index (OSDI) was also evaluated. Safety measures were assessed by the presence of adverse events.

Results

A total of 28 patients with mild to moderate dry eye were included in the pe

SUBMITTER: Llamas-Moreno JF 

PROVIDER: S-EPMC3686535 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature