Endoplasmic reticulum stress regulates rat mandibular cartilage thinning under compressive mechanical stress.

ABSTRACT: Compressive mechanical stress-induced cartilage thinning has been characterized as a key step in the progression of temporomandibular joint diseases, such as osteoarthritis. However, the regulatory mechanisms underlying this loss have not been thoroughly studied. Here, we used an established animal model for loading compressive mechanical stress to induce cartilage thinning in vivo. The mechanically stressed mandibular chondrocytes were then isolated to screen potential candidates using a proteomics approach. A total of 28 proteins were identified that were directly or indirectly associated with endoplasmic reticulum stress, including protein disulfide-isomerase, calreticulin, translationally controlled tumor protein, and peptidyl-prolyl cis/trans-isomerase protein. The altered expression

SUBMITTER: Li H 

PROVIDER: S-EPMC3689960 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature