Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.

ABSTRACT:

Background and objectives

Chronic widespread pain (CWP) is a common disorder affecting ∼10% of the general population and has an estimated heritability of 48-52%. In the first large-scale genome-wide association study (GWAS) meta-analysis, we aimed to identify common genetic variants associated with CWP.

Methods

We conducted a GWAS meta-analysis in 1308 female CWP cases and 5791 controls of European descent, and replicated the effects of the genetic variants with suggestive evidence for association in 1480 CWP cases and 7989 controls. Subsequently, we studied gene expression levels of the nearest genes in two chronic inflammatory pain mouse models, and examined 92 genetic variants previously described associated with pain.

Results

The minor C-allele of rs13361160 on c

SUBMITTER: Peters MJ 

PROVIDER: S-EPMC3691951 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature