Application of motif-based tools on evolutionary analysis of multipartite single-stranded DNA viruses.

ABSTRACT: Multipartite viruses contain more than one distinctive genome component, and the origin of multipartite viruses has been suggested to evolve from a non-segmented wild-type virus. To explore whether recombination also plays a role in the evolution of the genomes of multipartite viruses, we developed a systematic approach that employs motif-finding tools to detect conserved motifs from divergent genomic regions and applies statistical approaches to select high-confidence motifs. The information that this approach provides helps us understand the evolution of viruses. In this study, we compared our motif-based strategy with current alignment-based recombination-detecting methods and applied our methods to the analysis of multipartite single-stranded plant DNA viruses, including bipartite bego

SUBMITTER: Wang HI 

PROVIDER: S-EPMC3735576 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature