Ontology highlight
ABSTRACT:
SUBMITTER: Qi J
PROVIDER: S-EPMC3750989 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Qi Jianfei J Tripathi Manisha M Mishra Rajeev R Sahgal Natasha N Fazli Ladan L Ettinger Susan S Placzek William J WJ Claps Giuseppina G Chung Leland W K LW Bowtell David D Gleave Martin M Bhowmick Neil N Ronai Ze'ev A ZA
Cancer cell 20130301 3
Understanding the mechanism underlying the regulation of the androgen receptor (AR), a central player in the development of castration-resistant prostate cancer (CRPC), holds promise for overcoming the challenge of treating CRPC. We demonstrate that the ubiquitin ligase Siah2 targets a select pool of NCOR1-bound, transcriptionally-inactive AR for ubiquitin-dependent degradation, thereby promoting expression of select AR target genes implicated in lipid metabolism, cell motility, and proliferatio ...[more]