Anti-diabetic activity of active fractions of Stereospermum tetragonum DC and isolation of active principles.

ABSTRACT:

Objectives

To identify the active principles, determine the anti-diabetes activity of fraction of Stereospermum tetragonum root.

Materials and methods

The efficacy was evaluated in streptozotocin induced type 2 diabetic rats and the anti-hyperglycemic activity was studied by glucose tolerance test. The major active compounds were isolated by solvent fractionation and chromatographic techniques and characterized with spectral data.

Results

The active fraction of S. tetragonum showed presence of anti-diabetes mellitus activity in type-2 diabetic rats. It did not significantly influence insulin release from cultured islets. Two active principles (active at 2 mg/kg dose) were isolated and characterized with spectral data. One of them was identified as an iridoid type glyc

SUBMITTER: Bino Kingsley R 

PROVIDER: S-EPMC3758101 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature