Neurodevelopment in schizophrenia: the role of the wnt pathways.

ABSTRACT:

Objectives

To review the role of Wnt pathways in the neurodevelopment of schizophrenia.

Methods

SYSTEMATIC PUBMED SEARCH, USING AS KEYWORDS ALL THE TERMS RELATED TO THE WNT PATHWAYS AND CROSSING THEM WITH EACH OF THE FOLLOWING AREAS: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action.

Results

Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic drug action are Akt1, glycogen synthase kinase3beta, and beta-ca

SUBMITTER: Panaccione I 

PROVIDER: S-EPMC3763761 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature