Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.

ABSTRACT:

Background & aims

IL28B polymorphisms have been associated with both treatment induced and spontaneous clearance of hepatitis C virus (HCV). We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene. Here we analyzed the association of steatosis with IL28B genotype in treatment naïve patients with CHC.

Methods

Two independent cohorts of 145 genotype 1 infected patients from an antifibrotic study and 180 genotype 1 patients from Duke were analyzed for the presence and severity of steatosis in relation to the rs12979860 polymorphism at the IL28B locus. TaqMan assay based genotyping classified three groups CC, CT, and TT.

Results

CC genotype was

SUBMITTER: Tillmann HL 

PROVIDER: S-EPMC3763913 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature