Ruthenium catalyzed reductive coupling of paraformaldehyde to trifluoromethyl allenes: CF3-bearing all-carbon quaternary centers.

ABSTRACT: Trifluoromethyl substituted allenes engage in ruthenium catalyzed reductive couplings with paraformaldehyde to form products of hydrohydroxymethylation as single regioisomers. This method enables generation of CF3-bearing all-carbon quaternary stereocenters.

SUBMITTER: Sam B 

PROVIDER: S-EPMC3779475 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature