Endothelial protein C receptor and pediatric arterial stroke.
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ABSTRACT: Objective
The aim of this study was to investigate the endothelial protein C receptor (EPCR) gene A3 haplotype and plasma soluble EPCR (sEPCR) levels in Turkish pediatric arterial stroke patients.Materials and methods
We analyzed 44 pediatric arterial stroke patients and 75 healthy controls. Following DNA isolation, genotyping of the A3 haplotype was determined via PCR and RFLP. Additionally, fasting sEPCR levels were determined via ELISA.Results
There wasn't a significant difference in the sEPCR level between the control and patient groups, although the sEPCR level was higher in the patient group. We didn't observe a difference in the distribution of the CC and CG/GG genotypes between the control and patient groups.Conclusion
Further study on sEPCR levels at the onset of pediatric stroke is needed in order to reach a more definitive conclusion.Conflict of interest
None declared.
SUBMITTER: Akar N
PROVIDER: S-EPMC3781647 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Endothelial protein C receptor and pediatric arterial stroke.
Akar Nejat N Karabıyık Afife A Deda Gülhis G
Turkish journal of haematology : official journal of Turkish Society of Haematology 20130305 1
<h4>Objective</h4>The aim of this study was to investigate the endothelial protein C receptor (EPCR) gene A3 haplotype and plasma soluble EPCR (sEPCR) levels in Turkish pediatric arterial stroke patients.<h4>Materials and methods</h4>We analyzed 44 pediatric arterial stroke patients and 75 healthy controls. Following DNA isolation, genotyping of the A3 haplotype was determined via PCR and RFLP. Additionally, fasting sEPCR levels were determined via ELISA.<h4>Results</h4>There wasn't a significan ...[more]
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