Ontology highlight
ABSTRACT:
SUBMITTER: Gardner JM
PROVIDER: S-EPMC3804105 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Immunity 20130829 3
The autoimmune regulator (Aire) is essential for prevention of autoimmunity; its role is best understood in the thymus, where it promotes self-tolerance through tissue-specific antigen (TSA) expression. Recently, extrathymic Aire-expressing cells (eTACs) have been described in murine secondary lymphoid organs, but the identity of such cells and their role in immune tolerance remains unclear. Here we have shown that eTACs are a discrete major histocompatibility complex class II (MHC II)(hi), CD80 ...[more]