Aging is associated with highly defined epigenetic changes in the human epidermis.

ABSTRACT:

Background

Altered DNA methylation patterns represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Several studies have described global and complex age-related methylation changes, but their structural and functional significance has remained largely unclear.

Results

We have used transcriptome sequencing to characterize age-related gene expression changes in the human epidermis. The results revealed a significant set of 75 differentially expressed genes with a strong functional relationship to skin homeostasis. We then used whole-genome bisulfite sequencing to identify age-related methylation changes at single-base resolution. Data analysis revealed no global aberrations, but rather highly localized methylation changes, parti

SUBMITTER: Raddatz G 

PROVIDER: S-EPMC3819645 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature