Boosting prediction performance of protein-protein interaction hot spots by using structural neighborhood properties.

ABSTRACT: Binding of one protein to another in a highly specific manner to form stable complexes is critical in most biological processes, yet the mechanisms involved in the interaction of proteins are not fully clear. The identification of hot spots, a small subset of binding interfaces that account for the majority of binding free energy, is becoming increasingly important in understanding the principles of protein interactions. Despite experiments like alanine scanning mutagenesis and a variety of computational methods that have been applied to this problem, comparative studies suggest that the development of accurate and reliable solutions is still in its infant stage. We developed PredHS (Prediction of Hot Spots), a computational method that can effectively identify hot spots on protein-binding

SUBMITTER: Deng L 

PROVIDER: S-EPMC3822376 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature