Toenail iron, genetic determinants of iron status, and the risk of glioma.

ABSTRACT:

Purpose

Iron is essential for oxygen transport and oxidative metabolism; however, elevated iron stores can trigger overproduction of reactive oxygen species and induce DNA damage. Little is known about the association between body iron stores and glioma risk. This study examined the associations of iron levels measured in toenails and genetic variants linked to body iron stores with risk of glioma in a clinic-based case-control study.

Methods

Samples were collected a median of 24 days following glioma diagnosis in the cases (10th-90th percentile, range: 10-44 days). Nail iron levels were measured in 300 cases and 300 controls using neutron activation analysis. A total of 24 genetic variants associated with iron status were genotyped in 622 cases and 628 controls. Logistic re

SUBMITTER: Anic GM 

PROVIDER: S-EPMC3823695 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature