Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex.

ABSTRACT:

Background

Breast cancer is the leading cause of cancer death in women living in the western hemisphere. Despite major advances in first-line endocrine therapy of advanced oestrogen receptor (ER)-positive breast cancer, the frequent recurrence of resistant cancer cells represents a serious obstacle to successful treatment. Understanding the mechanisms leading to acquired resistance, therefore, could pave the way to the development of second-line therapeutics. To this end, we generated an ER-positive breast cancer cell line (MCF-7) with resistance to the therapeutic anti-oestrogen fulvestrant (FUL) and studied the molecular changes involved in resistance.

Methods

Naive MCF-7 cells were treated with increasing FUL concentrations and the gene expression profile of the resulting

SUBMITTER: Giessrigl B 

PROVIDER: S-EPMC3833203 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature