Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years.

ABSTRACT:

Importance

Postmenopausal hormone therapy with conjugated equine estrogens (CEEs) may adversely affect older women’s cognitive function. It is not known whether this extends to younger women.

Objective

To test whether prescribing CEE-based hormone therapy to postmenopausal women aged 50 to 55 years has longer-term effects on cognitive function.

Design

Trained, masked staff assessed participants with an annual telephone-administered cognitive battery that included measures of global and domain-specific cognitive functions. Cognitive testing was conducted an average of 7.2 years after the trials ended, when women had a mean age of 67.2 years, and repeated 1 year later. Enrollment occurred from 1996 through 1999.

Setting

Forty academic research centers.

Partici

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC3844547 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature