Prevalence of ATM Sequence Variants in Northern Plains American Indian Cancer Patients.

ABSTRACT:

Purpose

To identify sequence variants of the ataxia telangiectasia mutated (ATM) gene and establish their prevalence rate among American Indian (AI) as compared with non-AI cancer patients.

Materials and methods

DNA was isolated from blood samples collected from 100 AI and 100 non-AI cancer patients undergoing radiation therapy, and a blinded assessment of the ATM sequence was conducted. Quantitative PCR assessment of copy number for each exon was also performed. The main outcome measure was the prevalence of ATM variants in the two patient populations.

Results

No statistically significant differences for total prevalence of ATM variants among AI and non-AI patients were found. Of the 25 variants identified, 5 variants had a prevalence of >2%, of which 4 occurred at a

SUBMITTER: Petereit DG 

PROVIDER: S-EPMC3874556 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature