Human Papillomavirus Prevalence Among American Indian Women of the Great Plains.
Ontology highlight
ABSTRACT: Background
High-risk human papillomavirus (hrHPV) causes cervical cancer. In the United States, approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian (AI) women are insufficiently sampled to permit a population-specific estimate of hrHPV prevalence.Methods
Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. We estimated the population prevalence of hrHPV and identified predominant genotypes.Results
The combined prevalence of hrHPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 was 34.8%. HPV-51 (7.6%), HPV-58 (5.3%), HPV-52 (4.3%), HPV-18 (4.3%), and HPV-16 (3.9%) were most prevalent. hrHPV prevalence declined with age, from 42.2% in women aged 21-24 years to 27.9% in women aged 50-65 years.Conclusions
HPV-51 was the single most prevalent oncogenic genotype. The combined prevalence of hrHPV among AI women in our sample was high, particularly among women aged 50-65 years, for whom hrHPV prevalence was approximately triple that of other races. Cervical cancer screening efforts should be increased, particularly among women from the community aged 30 years and older.
SUBMITTER: Lee NR
PROVIDER: S-EPMC6386810 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Human Papillomavirus Prevalence Among American Indian Women of the Great Plains.
Lee Naomi R NR Winer Rachel L RL Cherne Stephen S Noonan Carolyn J CJ Nelson Lonnie L Gonzales Angela A AA Umans Jason G JG Buchwald Dedra D
The Journal of infectious diseases 20190201 6
<h4>Background</h4>High-risk human papillomavirus (hrHPV) causes cervical cancer. In the United States, approximately 40% of women aged 14-59 years from all racial and ethnic groups are infected with HPV, and prevalence typically declines with age. However, American Indian (AI) women are insufficiently sampled to permit a population-specific estimate of hrHPV prevalence.<h4>Methods</h4>Vaginal swabs were self-collected by 698 AI women aged 21-65 years from a tribal community in the Great Plains. ...[more]
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