Construction of a genome-scale kinetic model of mycobacterium tuberculosis using generic rate equations.

ABSTRACT: The study of biological systems at the genome scale helps us understand fundamental biological processes that govern the activity of living organisms and regulate their interactions with the environment. Genome-scale metabolic models are usually analysed using constraint-based methods, since detailed rate equations and kinetic parameters are often missing. However, constraint-based analysis is limited in capturing the dynamics of cellular processes. In this paper, we present an approach to build a genome-scale kinetic model of Mycobacterium tuberculosis metabolism using generic rate equations. M. tuberculosis causes tuberculosis which remains one of the largest killer infectious diseases. Using a genetic algorithm, we estimated kinetic parameters for a genome-scale metabolic model of M. tu

SUBMITTER: Adiamah DA 

PROVIDER: S-EPMC3901218 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature