Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A.

ABSTRACT: Salmonella enterica serovars Typhi and Paratyphi A isolates from human patients in France displaying different levels of resistance to quinolones or fluoroquinolones were studied for resistance mechanisms to these antimicrobial agents. All resistant isolates carried either single or multiple target gene mutations (i.e., in gyrA, gyrB, or parC) correlating with the resistance levels observed. Active efflux, through upregulation of multipartite efflux systems, has also been previously reported as contributing mechanism for other serovars. Therefore, we investigated also the occurrence of non-target gene mutations in regulatory regions affecting efflux pump expression. However, no mutation was detected in these regions in both Typhi and Paratyphi isolates of this study. Besides, no overexpres

SUBMITTER: Baucheron S 

PROVIDER: S-EPMC3902205 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature