Transcriptomic meta-analysis of multiple sclerosis and its experimental models.

ABSTRACT:

Background

Multiple microarray analyses of multiple sclerosis (MS) and its experimental models have been published in the last years.

Objective

Meta-analyses integrate the information from multiple studies and are suggested to be a powerful approach in detecting highly relevant and commonly affected pathways.

Data sources

ArrayExpress, Gene Expression Omnibus and PubMed databases were screened for microarray gene expression profiling studies of MS and its experimental animal models.

Study eligibility criteria

Studies comparing central nervous system (CNS) samples of diseased versus healthy individuals with n >1 per group and publically available raw data were selected.

Material and methods

Included conditions for re-analysis of differentially expressed g

SUBMITTER: Raddatz BB 

PROVIDER: S-EPMC3903571 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature