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Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1.

ABSTRACT: The unique functional properties and molecular identity of neuronal cell populations rely on cell type-specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain-containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1 resulted in a severe defect in the neuronal isoform content of the polymorphic synaptic receptors neurexin-1, -2, and -3. Thus, cell type-specific expression of SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo.

SUBMITTER: Iijima T

PROVIDER: S-EPMC3912522 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1.

Iijima Takatoshi T Iijima Yoko Y Witte Harald H Scheiffele Peter P

The Journal of cell biology 20140127 3

The unique functional properties and molecular identity of neuronal cell populations rely on cell type-specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain-containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1 resulted ...[more]

PMID: 24469635

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