Dietary restriction and fasting arrest B and T cell development and increase mature B and T cell numbers in bone marrow.

ABSTRACT: Dietary restriction (DR) delays ageing and extends life span. Both long- and short-term DR, as well as short-term fasting provide robust protection against many "neuronal and surgery related damaging phenomena" such as Parkinson's disease and ischemia-reperfusion injury. The exact mechanism behind this phenomenon has not yet been elucidated. Its anti-inflammatory actions prompted us to thoroughly investigate the consequences of DR and fasting on B and T cell compartments in primary and secondary lymphoid organs of male C57Bl/6 mice. In BM we found that DR and fasting cause a decrease in the total B cell population and arrest early B cell development, while increasing the number of recirculating mature B cells. In the fasting group, a significant reduction in peripheral B cell counts was ob

SUBMITTER: Shushimita S 

PROVIDER: S-EPMC3913690 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature