Ontology highlight
ABSTRACT:
SUBMITTER: Collins N
PROVIDER: S-EPMC6818271 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cell 20190801 5
Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation. This response was coordinated by glucocorticoids and associated with a profound remodeling of the BM compartment ...[more]