IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation.

ABSTRACT:

Background

Viral infections are the most frequent cause of asthma exacerbations and are linked to increased airway reactivity (AR) and inflammation. Mice infected with respiratory syncytial virus (RSV) during ovalbumin (OVA)-induced allergic airway inflammation (OVA/RSV) had increased AR compared with OVA or RSV mice alone. Furthermore, interleukin 17A (IL-17A) was only increased in OVA/RSV mice.

Objective

To determine whether IL-17A increases AR and inflammation in the OVA/RSV model.

Methods

Wild-type (WT) BALB/c and IL-17A knockout (KO) mice underwent mock, RSV, OVA or OVA/RSV protocols. Lungs, bronchoalveolar lavage (BAL) fluid and/or mediastinal lymph nodes (MLNs) were harvested after infection. Cytokine expression was determined by ELISA in the lungs or BAL fluid

SUBMITTER: Newcomb DC 

PROVIDER: S-EPMC3916091 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature