Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling.

ABSTRACT:

Background

Recently, evidence indicated that the rapamycin-eluting stent which was used worldwide may contribute to an increased risk for thrombosis. On the contrary, other researchers found it was safe. Thus, it is necessary to clarify the effect of rapamycin on thrombosis and the corresponding mechanisms.

Results

The effects of rapamycin in vivo were evaluated by modified deep vein thrombosis animal model. The platelets were from healthy volunteers and the platelet-endothelium (purchased from ATCC) adhesion in cultured endothelial cells was assessed. Membrane rufflings in endothelial cells were examined by confocal and electron microscope. Thrombus formation increased in rats that were injected with rapamycin. Electron microscope analysis exhibited microvilli on the rapamy

SUBMITTER: Jiang P 

PROVIDER: S-EPMC3936831 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature