Ontology highlight
ABSTRACT:
SUBMITTER: Wei WQ
PROVIDER: S-EPMC3944214 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20131004 3
Efforts to define the genetic architecture underlying variable statin response have met with limited success, possibly because previous studies were limited to effect based on a single dose. We leveraged electronic medical records (EMRs) to extract potency (ED50) and efficacy (Emax) of statin dose-response curves and tested them for association with 144 preselected variants. Two large biobanks were used to construct dose-response curves for 2,026 and 2,252 subjects on simvastatin and atorvastati ...[more]