Ontology highlight
ABSTRACT:
SUBMITTER: Helming KC
PROVIDER: S-EPMC3954704 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Nature medicine 20140223 3
Recent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-like), is frequently mutated across a variety of human cancers and also has bona fide tumor suppressor properties. Consequently, identification of vulnerabilities conferred by ARID1A mutation would have major relevance for human cancer. Here, using a broad screening approach, we identify ARID1B, an ARID1A homolog whose gene product is mutually exclusive with ARID1A in SWI/SNF complexes, as the number 1 gene pre ...[more]