Ontology highlight
ABSTRACT:
SUBMITTER: Smith JH
PROVIDER: S-EPMC3955693 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
BioMed research international 20140302
We evaluated single nucleotide polymorphism (SNP) detection via a target-capture, C-probe ligation, and RAM assay in a single-blind comparison to clinical samples that had been tested with FDA-cleared tests for up to 4 different vascular disease-related SNPs. In the RAM assay circulizable linear probes (C- or padlock probes) were annealed directly to genomic DNA, processed on a largely automated platform, and ligated C-probes were amplified by real-time RAM. After allele determinations were made ...[more]