New Taxane Diterpenoids from Taxus yunnanensis.

ABSTRACT: Three hitherto unknown taxane diterpenoids, namely baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis. Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 μM, respectively.

SUBMITTER: Hai P 

PROVIDER: S-EPMC3956972 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature