Ontology highlight
ABSTRACT:
SUBMITTER: Weits DA
PROVIDER: S-EPMC3959200 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Nature communications 20140306
In plant and animal cells, amino-terminal cysteine oxidation controls selective proteolysis via an oxygen-dependent branch of the N-end rule pathway. It remains unknown how the N-terminal cysteine is specifically oxidized. Here we identify plant cysteine oxidase (PCO) enzymes that oxidize the penultimate cysteine of ERF-VII transcription factors by using oxygen as a co-substrate, thereby controlling the lifetime of these proteins. Consequently, ERF-VII proteins are stabilized under hypoxia and a ...[more]