Ontology highlight
ABSTRACT:
SUBMITTER: Stevens A
PROVIDER: S-EPMC3959225 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Stevens A A Clayton P P Tatò L L Yoo H W HW Rodriguez-Arnao M D MD Skorodok J J Ambler G R GR Zignani M M Zieschang J J Della Corte G G Destenaves B B Champigneulle A A Raelson J J Chatelain P P
The pharmacogenomics journal 20130409 1
Individual responses to growth hormone (GH) treatment are variable. Short-term generation of insulin-like growth factor-I (IGF-I) is recognized as a potential marker of sensitivity to GH treatment. This prospective, phase IV study used an integrated genomic analysis to identify markers associated with 1-month change in IGF-I (ΔIGF-I) following initiation of recombinant human (r-h)GH therapy in treatment-naïve children with GH deficiency (GHD) (n=166) or Turner syndrome (TS) (n=147). In both GHD ...[more]