Ontology highlight
ABSTRACT:
SUBMITTER: Wang GX
PROVIDER: S-EPMC3964504 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Wang Guo-Xiao GX Cho Kae Won KW Uhm Maeran M Hu Chun-Rui CR Li Siming S Cozacov Zoharit Z Xu Acer E AE Cheng Ji-Xin JX Saltiel Alan R AR Lumeng Carey N CN Lin Jiandie D JD
Diabetes 20131230 4
Chronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs insulin sensitivity and systemic metabolism, in part, through the actions of proinflammatory cytokines. Whether obesity engages an adaptive mechanism to counteract chronic inflammation in adipose tissues has not been elucidated. Here we identified otopetrin 1 (Otop1) as a component of a counterinflammatory pathway that is induce ...[more]