Population differences concerning TNF-α gene polymorphisms in gastric carcinogenesis based on meta-analysis.

ABSTRACT:

Background

Recent meta-analyses have studied population differences concerning interleukin (IL)-1 gene polymorphisms in gastric carcinogenesis. In addition to the IL-1 gene cluster, candidate genes include those encoding the pro-inflammatory cytokine tumor necrosis factor (TNF)-α. The aim of the study was to systematically review the role of TNF-α-238 and TNF-α-308 gene polymorphisms (genotypes G/G, G/A, A/A) in gastric carcinogenesis by meta-analyzing all relevant studies to look for any differences concerning TNF-α gene polymorphisms in gastric carcinogenesis.

Methods

Extensive English language medical literature searches for human studies were performed up to the end of May 2013, using suitable keywords. Pooled estimates [o

SUBMITTER: Rokkas T 

PROVIDER: S-EPMC3982629 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature