Network-based penalized regression with application to genomic data.

ABSTRACT: Penalized regression approaches are attractive in dealing with high-dimensional data such as arising in high-throughput genomic studies. New methods have been introduced to utilize the network structure of predictors, for example, gene networks, to improve parameter estimation and variable selection. All the existing network-based penalized methods are based on an assumption that parameters, for example, regression coefficients, of neighboring nodes in a network are close in magnitude, which however may not hold. Here we propose a novel penalized regression method based on a weaker prior assumption that the parameters of neighboring nodes in a network are likely to be zero (or non-zero) at the same time, regardless of their specific magnitudes. We propose a novel non-convex penalty functio

SUBMITTER: Kim S 

PROVIDER: S-EPMC4007772 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature