Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study.

ABSTRACT:

Background

Cigarette smoking is the major cause of chronic obstructive pulmonary disease and emphysema. Recent studies suggest that susceptibility to cigarette smoke may vary by race/ethnicity; however, they were generally small and relied on self-reported race/ethnicity.

Objective

To test the hypothesis that relationships of smoking to lung function and per cent emphysema differ by genetic ancestry and self-reported race/ethnicity among Caucasians, African-Americans, Hispanics and Chinese-Americans.

Design

Cross-sectional population-based study of adults age 45-84 years in the USA.

Measurements

Principal components of genetic ancestry and continental ancestry estimated from one million genome-wide single nucleotide polymorphisms; pack-years of smoking; spirome

SUBMITTER: Powell R 

PROVIDER: S-EPMC4020409 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature