Ontology highlight
ABSTRACT:
SUBMITTER: Minkara MS
PROVIDER: S-EPMC4020587 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Minkara Mona S MS Ucisik Melek N MN Weaver Michael N MN Merz Kenneth M KM
Journal of chemical theory and computation 20140325 5
<i>Helicobacter pylori</i> have been implicated in an array of gastrointestinal disorders including, but not limited to, gastric and duodenal ulcers and adenocarcinoma. This bacterium utilizes an enzyme, urease, to produce copious amounts of ammonia through urea hydrolysis in order to survive the harsh acidic conditions of the stomach. Molecular dynamics (MD) studies on the <i>H. pylori</i> urease enzyme have been employed in order to study structural features of this enzyme that may shed light ...[more]