Imaging and cerebrospinal fluid biomarkers in the search for Alzheimer's disease mechanisms.

ABSTRACT:

Background

The pathophysiological process of Alzheimer's disease (AD) begins many years before the emergence of clinical symptoms (preclinical AD). A hypothetical biomarker progression in the pathogenesis of AD has been suggested, beginning with the deposition of amyloid-β (Aβ) and followed by increases in neurofibrillary tangles, synaptic loss, hippocampal atrophy, and lastly, cognitive impairment.

Objective

We explored the effect of several risk factors for AD on the pattern of AD biomarker expression in normal subjects.

Methods

AD biomarker evidence was examined at baseline in 96 cognitively normal elderly subjects with none or at least one of the following: ApoE4+ allele, a maternal history of AD (mFHx), sleep-disordered breathing (SDB), and longitudinal evidence

SUBMITTER: Osorio RS 

PROVIDER: S-EPMC4022141 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature