Quantitative proteomics analysis of early recurrence/metastasis of huge hepatocellular carcinoma following radical resection.

ABSTRACT:

Background

Hepatic resection is the preferred treatment for huge hepatocellular carcinoma (>10 cm in diameter; H-HCC). However, the patients with H-HCC suffer from poor prognosis due to the early recurrence/metastasis. The underlying mechanism of H-HCC's early recurrence/metastasis is currently not well understood.

Results

Here, we describe an Isobaric Tags for relative and absolute quantification (iTRAQ)-based quantitative proteomics approach to analyze the early recurrence/metastasis related proteins of H-HCC after radical resection through multidimensional chromatography coupled with tandem mass spectrometry (2DLC-MS/MS). The different protein expression profiles between the early recurrence/metastasis within 6 months(R/M≤6months) and late recurrence/metastasis within 6-1

SUBMITTER: Huang X 

PROVIDER: S-EPMC4023177 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature