Effect of recombinant human MG53 protein on tourniquet-induced ischemia-reperfusion injury in rat muscle.

ABSTRACT:

Introduction

Skeletal muscle ischemia-reperfusion injury (I-R) is a complex injury process that includes damage to the sarcolemmal membrane, contributing to necrosis and apoptosis. MG53, a muscle-specific TRIM family protein, has been shown to be essential for regulating membrane repair and has been shown to be protective against cardiac I-R and various forms of skeletal muscle injury. The purpose of this study was to determine if recombinant human MG53 (rhMG53) administration offered protection against I-R.

Methods

rhMG53 was administered to rats immediately before tourniquet-induced ischemia and again immediately before reperfusion. Two days later muscle damage was assessed histologically.

Results

rhMG53 offered no protective effect, as evidenced primarily by simila

SUBMITTER: Corona BT 

PROVIDER: S-EPMC4028410 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature