Studies of metabolite-protein interactions: a review.

ABSTRACT: The study of metabolomics can provide valuable information about biochemical pathways and processes at the molecular level. There have been many reports that have examined the structure, identity and concentrations of metabolites in biological systems. However, the binding of metabolites with proteins is also of growing interest. This review examines past reports that have looked at the binding of various types of metabolites with proteins. An overview of the techniques that have been used to characterize and study metabolite-protein binding is first provided. This is followed by examples of studies that have investigated the binding of hormones, fatty acids, drugs or other xenobiotics, and their metabolites with transport proteins and receptors. These examples include reports that have co

SUBMITTER: Matsuda R 

PROVIDER: S-EPMC4032809 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature