Deciphering the mechanism behind Fibroblast Growth Factor (FGF) induced biphasic signal-response profiles.

ABSTRACT:

Background

The Fibroblast Growth Factor (FGF) pathway is driving various aspects of cellular responses in both normal and malignant cells. One interesting characteristic of this pathway is the biphasic nature of the cellular response to some FGF ligands like FGF2. Specifically, it has been shown that phenotypic behaviors controlled by FGF signaling, like migration and growth, reach maximal levels in response to intermediate concentrations, while high levels of FGF2 elicit weak responses. The mechanisms leading to the observed biphasic response remains unexplained.

Results

A combination of experiments and computational modeling was used to understand the mechanism behind the observed biphasic signaling responses. FGF signaling involves a tertiary surface interaction that we c

SUBMITTER: Kanodia J 

PROVIDER: S-EPMC4036111 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature