Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV.

ABSTRACT:

Background

microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence suggests miR-24 plays important roles in human carcinogenesis. However, its precise biological role remains largely elusive. This study examined the role of miR-24 in gastric cancer (GC).

Methods

The expression of miR-24 in GC tissues compared with matched non-tumor tissues and GC cells was detected by qRT-PCR. Synthetic short single or double stranded RNA oligonucleotides and lentiviral vectors were used to regulate miR-24 expression in GC cells to investigate its function in vitro and in vivo.

Results

miR-24 was significantly downregulated in GC tissues c

SUBMITTER: Duan Y 

PROVIDER: S-EPMC4041902 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature