First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants.

ABSTRACT:

Purpose

Pregnancy characteristics have been associated with breast cancer risk, but information is limited on their relationship with breast density. Our objective was to examine the relationship between first pregnancy characteristics and later life breast density, and whether the association is modified by genotype.

Methods

The Marin Women's Study was initiated to examine breast cancer in a high-incidence mammography population (Marin County, CA). Reproductive characteristics and pregnancy information including pregnancy-induced hypertension (PIH) were self-reported at the time of mammography. Forty-seven candidate single nucleotide polymorphisms were obtained from saliva samples; seven were assessed in relation to PIH and percent fibroglandular volume (%FGV). Breast densi

SUBMITTER: Prebil LA 

PROVIDER: S-EPMC4048469 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature